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- Title
Experimental study of the effect of Gumibao recipe on blood vessel repairing in steroid-induced necrosis of the femoral head in rats.
- Authors
JI Wanbo; LIU Guanhong; LIU Jingtao; ZHANG Zhigang; JIANG Hong
- Abstract
Objective To explore the effect of Gumibao recipe on vessel repairing in the steroid-induced necrosis of the femoral head (SINFH) in rats, thus reveling its partial mechanism. Methods One hundred and seventy four 2-month-old SD rats were randomly assigned to 5 groups; blank control group, model group. Gumibao recipe groups (high- medium- and low-dose). Eight rats, half male and half female, were in each group. SINFH models were established according to S. Okazaki's technique. High-medium- or low-dose of Gumibao recipe suspension was gavaged to the rats. Equal amount of normal saline was gavaged to the rats in blank control group. Four animals were randomly sacrificed in each group after 4,8, and 12 weeks drug intervention. VEGF immunohistochemical staining and transmission electron microscopy (TEM) ultrastaictural were performed. Data between time points and groups were analyzed. Results HE staining and TEM observation confirmed the success of the SINFH model. The expression of VEGF in Gumibao groups was significantly higher than that in the model group (P < 0.05) and it gradually returned to normal the level. The expression was the highest in the low-dose group. Conclusion Gumibao recipe can promote the repairing of the femoral head, stimulate the new blood vessel formation, and speed up bone formation.
- Publication
Chinese Journal of Osteoporosis, 2014, Vol 20, Issue 10, p1148
- ISSN
1006-7108
- Publication type
Article