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- Title
DrosophilaBys is nuclear and shows dynamic tissue-specific expression during development.
- Authors
Stewart, Mary; Nordquist, Erik
- Abstract
Although thebys-like family of genes has been conserved from yeast to humans, it is not apparent to what extent the function of Bys-like proteins has been conserved across phylogenetic groups. Human Bystin is thought to function in a novel cell adhesion complex involved in embryo implantation. The product of the yeastbys-like gene,Enp1, is nuclear and has a role in pre-ribosomal RNA (pre-rRNA) splicing and ribosome biogenesis. To gain insight into the function of theDrosophila melanogasterbys-like family member, termedbys, we examinedbysmRNA expression and the localization of Bys protein. In embryos,bysmRNA is expressed in a tissue-specific pattern during gastrulation. In the larval wing imaginal disc,bysmRNA is expressed in the ventral and dorsal regions of the wing pouch, regions that give rise to epithelia that adhere to one another after the wing disc everts. ThebysmRNA expression patterns could be interpreted as being consistent with a role for Bys in events requiring cell-cell interactions. However, embryonicbysmRNA expression patterns mirror those of genes that are potential targets of the growth regulator Myc and encode nucleolar proteins implicated in cell growth. Additionally, in Schneider line 2 (S2) cells, an epitope-tagged Bys protein is localized to the nucleus, suggesting thatDrosophilaBys function may be conserved with that of yeast Enp1.
- Subjects
DROSOPHILA; GASTRULATION; DEVELOPMENTAL biology; EMBRYOLOGY; RIBOSOMES; PHYLOGENY
- Publication
Development Genes & Evolution, 2005, Vol 215, Issue 2, p97
- ISSN
0949-944X
- Publication type
Article
- DOI
10.1007/s00427-004-0447-8