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- Title
Ommaya reservoir placement using ultrasound guidance via anterior fontanelle combined with frameless electromagnetic neuronavigation in patients with mucopolysaccharidosis type 2: Case reports and review of the literature.
- Authors
Mizushima, Makoto; Kawabori, Masahito; Yamazaki, Kazuyoshi; Egawa, Kiyoshi; Fujimura, Miki
- Abstract
Mucopolysaccharidosis type II (MPS II) results from the genetic deficiency of a lysosomal enzyme and is associated with central nervous system (CNS) dysfunction. In Japan, in addition to intravenous enzyme administration, intracerebroventricular enzyme delivery through the Ommaya reservoir has recently gained approval. Nevertheless, the ideal approach for safely implanting the reservoir into the narrow ventricles of infantile MPS II patients remains uncertain. In this report, we present two cases of successful reservoir placement in infantile MPS II patients using ultrasound guidance via the anterior fontanelle, coupled with flameless electromagnetic neuronavigation.
- Subjects
JAPAN; LITERATURE reviews; MUCOPOLYSACCHARIDOSIS; GLYCOGEN storage disease type II; ENZYME deficiency; ULTRASONIC imaging; CENTRAL nervous system
- Publication
Child's Nervous System, 2024, Vol 40, Issue 5, p1603
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-023-06265-9