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- Title
Spectrophotometric Assay of Salbutamol Sulphate in Pharmaceutical Preparations by Coupling with Diazotized ρ-bromoaniline.
- Authors
Hamoudi, Tamathir A.
- Abstract
In this research, salbutamol sulphate (SAS) has been determined by a simple, rapid and sensitive spectrophotometric method. Salbutamol sulphate in this method is based on the coupling of SAS with diazotized ρ- bromoaniline reagent in alkaline medium of Triton X-100 (Tx) to form an orange azo dye which is stable and water-soluble. The azo dye is exhibiting maximum absorption at 441 nm. A 10 - 800 μg of SAS is obeyed of Beer's law in a final volume of 20 ml, i.e., 0.5- 40 ppm with ε, the molar absorptivity of 48558 L.mol-1.cm-1 and Sandell's sensitivity index of 0.01188 μg.cm-2. This new method does not need solvent extraction or temperature control which is well applied to determine SAS in different types of pharmaceutical preparations.
- Subjects
DRUGS; BEER-Lambert law; ALBUTEROL; TRITON X-100; SULFATES; AZO dyes
- Publication
Baghdad Science Journal, 2019, Vol 16, Issue 3, p610
- ISSN
2078-8665
- Publication type
Article
- DOI
10.21123/bsj.2019.16.3.0610