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- Title
Suppression of tumour necrosis factor-α expression in leprosy skin lesions during treatment for leprosy.
- Authors
Sugita, Y.; Miyamoto, M.; Koseki, M.; Ishii, N.; Nakajima, H.
- Abstract
The expression of tumour necrosis factor (TNF)-α in leprosy skin lesions was examined before and during successful treatment iii a patient with borderline lepromatous leprosy. Before treatment, immunohistochemical staining of a skin biopsy specimen showed diffuse TNF-α deposits in granulomas and significant TNF-α deposits on infiltrated mononuclear cells. After 1 year's treatment the skin lesions exhibited a reduction in granulomas. and a concomitant reduction in deposits of TNF-α. Furthermore. the level of expression of TNF-α messenger RNA, as examined using a reverse transcriptase polymerase chain reaction met hod. was reduced markedly after treatment. These findings provide evidence for a correlation between the expression of TNF-α and disease activity suggesting that TNF-α is a useful prognostic' indicator for inflammation in leprosy.
- Subjects
MYCOBACTERIAL diseases; TUMORS; NECROSIS; RNA; HANSEN'S disease; GRANULOMA; POLYMERASE chain reaction
- Publication
British Journal of Dermatology, 1997, Vol 136, Issue 3, p393
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1997.tb14952.x