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- Title
Phenotypic analysis of CD23<sup>+</sup> peripheral blood mononuclear cells in atopic dermatitis.
- Authors
Nakamura, K.; Okubo, Y.; Minami, M.; Furue, M.; Ishibashi, Y.
- Abstract
There is an increase in the number of CD23+ cells in peripheral blood mononuclear cells (PBMC) in atopic dermatitis (AD). We analysed the subpopulation of CD23+ PBMC in 11 patients with AD and in 10 healthy controls and found that B cells (CD20+) and non-T, non-B cells (CD3- CD20-) (mainly monocytes) were responsible for the elevation of CD23+ cells. CD23+ T cells (CD3+) comprised only 4.6% of total CD23+ cells in AD. The percentage of CD23+ cells did not correlate with the serum log IgE level nor with clinical severity of AD. Interleukin 4 (IL-4) induced the expression of CD23 antigen in PBMC both in AD and in healthy controls in a dose-dependent manner in vitro. This enhancing effect of IL-4 was completely abrogated by the addition of anti-lL-4 monoclonal antibody. Other cytokines such as IL-1, IL-2, IL-3, IFN-α, IFN-γ and TNF-α had no significant effects on CD23 expression.
- Subjects
ATOPIC dermatitis; SKIN inflammation; CD23 antigen; B cells; GLYCOPROTEINS; CYTOLOGY; DERMATOLOGY
- Publication
British Journal of Dermatology, 1991, Vol 125, Issue 6, p543
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1991.tb14791.x