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- Title
IgE-mediated anaphylactic reaction to purified and recombinant factor VIII in a patient with severe haemophilia A.
- Authors
KADAR, J. G.; SCHUSTER, J.; HUNZELMANN, N.
- Abstract
We report a 51-year-old patient with severe haemophilia A developing a severe life-threatening anaphylactic reaction to recombinant factor VIII (rFVIII). Anaphylactic reactions are a rare but well-known side effect of FVIII products. The nature of these reactions could not be clarified as previous studies failed to demonstrate a specific IgE response. Here, we could prove a grade 3 anaphlyactic reaction as an IgE-mediated response to rFVIII for the first time by Western blotting.
- Subjects
BLOOD coagulation factor VIII antibodies; RECOMBINANT antibodies; HEMOPHILIA; SERUM sickness; WESTERN immunoblotting
- Publication
Haemophilia, 2007, Vol 13, Issue 1, p104
- ISSN
1351-8216
- Publication type
Article
- DOI
10.1111/j.1365-2516.2006.01339.x