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- Title
Expression of immune modulator cytokines in human fulminant amoebic colitis.
- Authors
SIERRA-PUENTE, R. E.; CAMPOS-RODRÍGUEZ, R.; JARILLO-LUNA, R. A.; MUÑOZ-FERNÁNDEZ, L.; RODRÍGUEZ, M. G.; MUÑOZ-ORTEGA, M. H.; VENTURA-JUÁREZ, J.
- Abstract
Human fulminant amoebic colitis (FAC) is characterized by ulceration and inflammation of the colon. The specific mixture of pro-inflammatory and anti-inflammatory cytokines may participate in either the host defense or in the pathogenesis of amoebic colitis. Therefore, we studied the expression of IL-8, IL-10, IL-4, TGF-β and IFN-γ in human FAC patients and controls through immunohistochemistry analysis. The number of cells expressing IL-8, IL-4 and IL-10 was significantly enhanced in all FAC samples compared to the control samples. However, the expression of TGF- β in patients was low in the colonic mucosa and high in the lamina propria compared with the control. No expression of IFN-γ was found in the controls or FAC samples. The production of IL-8 by intestinal epithelial cells may play a role in the pathogenesis of amoebic infection, because this cytokine attracts neutrophils, which lead to an inflammatory reaction that results in tissue damage. The predominant expression of the macrophage down-regulating cytokines, IL-4, IL-10 and TGF-β, or the Th2-type immune response could inhibit a cell-mediated immune response, which in turn would facilitate parasite invasion in these tissues.
- Subjects
GENE expression; IMMUNOREGULATION; CYTOKINES; MALIGNANT hyperthermia; AMOEBA; COLITIS
- Publication
Parasite Immunology, 2009, Vol 31, Issue 7, p384
- ISSN
0141-9838
- Publication type
Article
- DOI
10.1111/j.1365-3024.2009.01118.x