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- Title
Is hypoxemia explained by intracardiac or intrapulmonary shunt in COVID-19-related acute respiratory distress syndrome?
- Authors
Masi, Paul; Bagate, François; d'Humières, Thomas; Al-Assaad, Lara; Abou Chakra, Laure; Derumeaux, Genevieve; Mekontso Dessap, Armand
- Abstract
Hypoxemia is the main feature of COVID-19-related acute respiratory distress syndrome (C-ARDS), but its underlying mechanisms are debated, especially in patients with low respiratory system elastance (Ers). We assessed 60 critically ill patients hospitalized in our intensive care unit for C-ARDS. We used contrast transthoracic echocardiography to assess patent foramen ovale (PFO) shunt and transpulmonary bubble transit (TPBT). The median Ers was 32 cmH2O/L. PFO shunt was detected in six (10%) patients and TPBT in 12 (20%) patients. PFO shunt and TPBT were similar in patients with higher or lower Ers. In conclusion, PFO and TPBT do not seem to be the main drivers of hypoxemia in C-ARDS, especially in patients with lower Ers.
- Subjects
ADULT respiratory distress syndrome; ATRIAL septal defects; RESPIRATORY organs; INTENSIVE care units
- Publication
Annals of Intensive Care, 2020, Vol 10, Issue 1, p1
- ISSN
2110-5820
- Publication type
Letter
- DOI
10.1186/s13613-020-00726-z