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- Title
Role of probiotics in the prevention of the enteric colonization by Candida in preterm newborns: incidence of late-onset sepsis and neurological outcome.
- Authors
Romeo, M. G.; Romeo, D. M.; Trovato, L.; Oliveri, S.; Palermo, F.; Cota, F.; Betta, P.
- Abstract
Objective:To evaluate the efficacy of probiotics in the prevention of gastrointestinal colonization by Candida species, of late-onset sepsis and neurological outcome in preterm newborns.Study Design:A prospective study was conducted in 249 preterms who were subdivided into three groups: one group (n=83) was supplemented with Lactobacillus (L.) reuteri, one group with L. rhamnosus (n=83) and the other with no supplementation (n=83). The fungal colonization in the gastrointestinal tract, the late onset of sepsis and clinical parameters were recorded. A neurological structured assessment was further performed at 1 year of age.Result:Candida stool colonization was significantly higher (P<0.01) in the control group than in the groups treated with probiotics. The L. reuteri group presented a significantly higher reduction in gastrointestinal symptoms than did the L. rhamnosus and control groups. Infants treated with probiotics showed a statistically significant lower incidence of abnormal neurological outcome than did the control group.Conclusion:The use of both probiotics seems to be effective in the prevention of gastrointestinal colonization by Candida, in the protection from late-onset sepis and in reducing abnormal neurological outcomes in preterms.
- Subjects
ITALY; ACADEMIC medical centers; ANALYSIS of variance; CANDIDIASIS; CHI-squared test; CLINICAL trials; HOST-bacteria relationships; NEONATAL diseases; LONGITUDINAL method; EVALUATION of medical care; NURSING assessment; STATISTICAL sampling; SEPSIS; STATISTICS; PROBIOTICS; DISEASE incidence; DISEASE complications
- Publication
Journal of Perinatology, 2011, Vol 31, Issue 1, p63
- ISSN
0743-8346
- Publication type
Article
- DOI
10.1038/jp.2010.57