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- Title
Perinatal management of fetal hemolytic disease due to Rh incompatibility combined with fetal alloimmune thrombocytopenia due to HPA-5b incompatibility.
- Authors
Schild, R. L.; Hoch, J.; Plath, H.; Geißen, C.; Fahnenstich, H.; Dame, C.; Hansmann, M.
- Abstract
We report our experience in the perinatal management of a complex case of fetal hemolytic disease primarily due to Rhesus incompatibility combined with fetal alloimmune thrombocytopenia. The lowest fetal hemoglobin and platelet levels were 2.6 g/dl and 13 000/µl, respectively. Intrauterine treatment consisted of six transfusions of packed red cells into the umbilical vein and one transfusion of platelets. The neonate required four transfusions of packed red cells to correct her hyporegenerative erythropoiesis. Postnatal management also included one platelet transfusion, intravenous immunoglobulins and erythropoietin. Although some degree of fetal thrombocytopenia may invariably be found in fetal red cell incompatibility, other rare causes need to be excluded.
- Subjects
ERYTHROBLASTOSIS fetalis; THROMBOCYTOPENIA; BLOOD transfusion reaction; FETAL diseases
- Publication
Ultrasound in Obstetrics & Gynecology, 1999, Vol 14, Issue 1, p64
- ISSN
0960-7692
- Publication type
Article
- DOI
10.1046/j.1469-0705.1999.14010064.x