We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Real-life analysis of the causes of death in patients consecutively followed for giant cell arteritis in a French centre of expertise.
- Authors
Antonini, Luca; Dumont, Anael; Lavergne, Amandine; Castan, Paul; Barakat, Clivia; Gallou, Sophie; Sultan, Audrey; Deshayes, Samuel; Aouba, Achille; Boysson, Hubert de
- Abstract
Objectives To describe, in a real-life setting, the direct causes of death in a cohort of consecutive patients with GCA. Methods We retrospectively analysed the deaths that occurred in a cohort of 470 consecutive GCA patients from a centre of expertise between January 2000 and December 2019. Among the 120 patients who died, we retrieved data from the medical files of 101 patients. Results Cardiovascular events were the dominant cause of death (n = 41, 41%) followed by infections (n = 22, 22%), geriatric situations (i.e. falls or senile deterioration; n = 17, 17%) and cancers (n = 15, 15%). Patients in each of these four groups were compared with the other deceased patients pooled together. Patients who died from cardiovascular events were more frequently male (46 vs 27%; P = 0.04) with a past history of coronary artery disease (29 vs 8%; P = 0.006). Patients who died from infections mostly had ongoing glucocorticoid treatment (82 vs 53%; P = 0.02) with higher cumulative doses (13 994 vs 9150 mg; P = 0.03). Patients who died from geriatric causes more frequently had osteoporosis (56 vs 17%; P = 0.0009) and had mostly discontinued glucocorticoid treatment (76 vs 33%; P = 0.001). The predictive factors of death in multivariate analysis were a history of coronary disease [hazard ratio (HR) 2.39; 95% CI 1.27, 4.21; P = 0.008], strokes at GCA diagnosis (HR 2.54; 95% CI 1.05, 5.24; P = 0.04), any infection during follow-up (HR 1.93; 95% CI 1.24, 2.98; P = 0.004) and fever at GCA diagnosis (HR 1.99; 95% CI 1.16, 3.28; P = 0.01). Conclusion Our study provides real-life insight on the cause-specific mortality in GCA patients.
- Subjects
MORTALITY risk factors; GIANT cell arteritis diagnosis; CAUSES of death; GLUCOCORTICOIDS; CONFIDENCE intervals; STROKE; FEVER; GERIATRICS; MULTIVARIATE analysis; GIANT cell arteritis; CARDIOVASCULAR diseases; RISK assessment; INFECTION; COMPARATIVE studies; OSTEOPOROSIS; TUMORS
- Publication
Rheumatology, 2021, Vol 60, Issue 11, p5080
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/keab222