We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population.
- Authors
Imaizumi, Takeshi; Higaki, Yasuki; Hara, Megumi; Sakamoto, Tatsuhiko; Horita, Mikako; Mizuta, Toshihiko; Eguchi, Yuichiro; Yasutake, Tsutomu; Ozaki, Iwata; Yamamoto, Kyosuke; Onohara, Shingo; Kawazoe, Seiji; Shigematsu, Hirohisa; Koizumi, Shunzo; Kudo, Sho; Tanaka, Keitaro
- Abstract
Limited epidemiological evidence suggests that genetic polymorphisms of drug-metabolizing enzymes such as cytochrome P450 (CYP), glutathione S-transferase (GST) and N-acetyltransferase (NAT) may be involved in tobacco-related hepatocarcinogenesis. We conducted a case–control study, including 209 incident cases with hepatocellular carcinoma (HCC) and two different control groups [275 hospital controls and 381 patients with chronic liver disease (CLD) without HCC], to investigate whether CYP1A1, CYP1A2, CYP2A6, CYP2E1, GSTM1 and NAT2 polymorphisms are related to the risk of HCC with any interaction with cigarette smoking. Overall, no significant associations with HCC were observed for any genotypes against either control group. However, we found a significant interaction (P = 0.0045) between CYP1A2 -3860G>A polymorphism and current smoking on HCC risk when we compared HCC cases with CLD patients; adjusted odds ratios [ORs; and 95% confidence intervals (CIs)] for G/A and A/A genotypes relative to G/G genotype were 0.28 (0.12–0.66) and 0.18 (0.04–0.94), respectively, among current smokers (P trend = 0.002), as compared with 1.28 (0.80–2.06) and 0.76 (0.34–1.71), respectively, among never/former smokers (P trend = 0.96). Similarly, in CYP1A2 G/G genotype, significant risk increase was observed for current smoking (OR = 4.08, 95% CI = 2.02–8.25) or more recent cigarette use (e.g. pack-years during last 5 years, P trend = 0.0003) but not in G/A and A/A genotypes combined (OR for current smoking = 1.39, 95% CI = 0.63–3.03; P trend for pack-years during last 5 years = 0.40). These results suggest that the CYP1A2 -3860G>A polymorphism modifies the smoking-related HCC risk among CLD patients.
- Subjects
GENETIC polymorphisms; ENZYMES; CYTOCHROME P-450; GLUTATHIONE; LIVER diseases
- Publication
Carcinogenesis, 2009, Vol 30, Issue 10, p1729
- ISSN
0143-3334
- Publication type
Article
- DOI
10.1093/carcin/bgp191