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- Title
Case report: Massive hepatocellular carcinoma with complete response to the non-surgical systematic treatment strategy.
- Authors
Yun Li; Yanzhen Lai; Xuqiang Luo; Jian Wu; Kunpeng Wu; Haiqing Ma
- Abstract
Background: The five-year recurrence rate of hepatocellular carcinoma (HCC) remains as high as 70%. A complete clinical response has not been observed without surgical resection. Here, we report a rare case of clinical complete response and long-term survival in a patient with massive HCC receiving treatment with immunotherapy, anti-angiogenic therapy, and radiotherapy. Case description: A 38-year-old woman presented to our hospital for abdominal pain that persisted for 3 months. She was diagnosed as Barcelona Clinic Liver Cancer(BCLC) stage A, with a Cancer of the Liver Italian Program (CLIP) score of 3, American Joint Committee on Cancer (AJCC) Tumor-Node-Metastasis (TNM) staging systems stage IB. She refused surgical resection and trans-arterial chemoembolization and accepted a non-invasive systematic treatment strategy involving immunotherapy, anti-angiogenic therapy, and radiotherapy. Her tumor burden decreased, and she experienced partial response before radiotherapy. Following radiotherapy, she experienced a complete clinical response and has been alive for more than 36 months after her initial presentation. She is currently alive. Conclusion: A non-invasive systematic treatment strategy is a potential radical treatment option for patients with massive HCC.
- Subjects
LIVER cancer; NEOVASCULARIZATION inhibitors; SURGICAL excision; THERAPEUTICS; ABDOMINAL pain; HEPATOCELLULAR carcinoma
- Publication
Frontiers in Oncology, 2024, p1
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2024.1291131