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- Title
Network-targeting combination therapy of leptomeningeal glioblastoma using multiple synthetic lethal strategies: a case report.
- Authors
Castro, Michael P.; Sipos, Bence; Biskup, Saskia; Kahn, Nina
- Abstract
Network targeting of disease-specific nodes represents a useful principle for designing combination cancer therapy. In this case of a patient with relapsed leptomeningeal glioblastoma, comprehensive molecular diagnosis led to the identification of a disease network characterized by multiple disease-specific synthetic lethal vulnerabilities involving DNA repair, REDOX homeostasis, and impaired autophagy which suggested a novel network-targeting combination therapy (NTCT). A treatment regimen consisting of lomustine, olaparib, digoxin, metformin, and high dose intravenous ascorbate was employed using the principle of intra-patient dose escalation to deliver the treatment with adequate safety measures to achieve a definitive clinical result.
- Subjects
GLIOBLASTOMA multiforme; MENINGEAL cancer; DNA repair; MOLECULAR diagnosis; CANCER treatment; DIGOXIN
- Publication
Frontiers in Oncology, 2023, p1
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2023.1210224