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- Title
Development of the Brazilian anti Schistosomiasis vaccine based on the recombinant fatty acid binding protein Sm14 plus GLA-SE adjuvant.
- Authors
Tendler, Miriam; Almeida, Marilia; Simpson, Andrew
- Abstract
Data herein reported and discussed refer to vaccination with the recombinant fatty acid binding protein (FABP) family member of the schistosomes, called Sm14. This antigen was discovered and developed under a Brazilian platform led by the Oswaldo Cruz Foundation, from the Health Ministry in Brazil, and was assessed for safety and immunogenicity in healthy volunteers. This paper reviews past and recent outcomes of developmental phases of the Sm14-based anti schistosomiasis vaccine addressed to, ultimately, impact transmission of the second most prevalent parasitic endemic disease worldwide.
- Subjects
BRAZIL; SCHISTOSOMIASIS vaccines; FATTY acid-binding proteins; ANTIGENS; SCHISTOSOMA mansoni; PUBLIC health
- Publication
Frontiers in Immunology, 2015, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2015.00218