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- Title
Antimicrobial and radical scavenging effects of alkaloid extracts from Rhizophora mucronata.
- Authors
Gurudeeban, S.; Ramanathan, T.; Satyavani, K.
- Abstract
During the last few decades, a substantial body of research has been directed toward the free-radical scavenging activity. Inflammation reactions and other cell damage frequently begin with oxidative stress, over-production of reactive oxygen species, and development of multidrug-resistant bacteria. Rhizophora mucronata is a mangrove species that belongs to Rhizophoraceae family and widely occurs on the south-east coast of India. Due to evidently inadequate scientific evaluation of this species, our present investigation was focused on the isolation and quantification of alkaloid-rich extracts of R. mucronata and in vitro estimation of their free-radical scavenging potential . As a result, it was established that the alkaloid-rich extracts contain ajmalicine, vindoline, catharanthine, and serpentine bioactive components. Antimicrobial activity tests showed maximum zone of inhibition (19.56 ± 0.19) in Staphylococcus aureus in comparison to other bacteria isolated from diabetic foot ulcer. The results obtained in the present study indicate that alkaloid-rich fraction of R. mucronata is a high-quality source of natural antibacterial and antioxidant formulations.
- Subjects
ANTI-infective agents; FREE radical scavengers; PHYSIOLOGICAL effects of alkaloids; RHIZOPHORA mucronata; INFLAMMATION; OXIDATIVE stress; DRUG resistance in bacteria
- Publication
Pharmaceutical Chemistry Journal, 2013, Vol 47, Issue 1, p50
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-013-0895-4