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- Title
An Overview of Biomarkers for Drug-Induced Toxicity.
- Authors
Upadhyay, Shikha; Jadon, Arvind Singh; Singh, Gurdeep
- Abstract
Minimizing toxicity remains one of the major barriers to bringing a drug to market. Approximately 91% of all developed compounds fail because of adverse or toxic effects of the candidate during clinical development. In addition, drug induced kidney injury, especially of patients in intensive care units, is very often a cause of Acute Kidney Injury. The need for diagnostic tools to identify drug-induced toxicity has been emphasized by the ICH regulated agencies. This has lead to multiple national and international projects focusing on the identification of novel biomarkers to enhance drug development. Several parameters related to cellular toxicity are known and have been used for several decades like serum creatinine, body weight, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), glutathione disulfide (GSSG), nicotinamide adenine dinucleotide phosphate (NADPH) and malondialdehyde (MDA). These biomarkers were mainly identified and qualified in rat but also for humans, several biomarkers have been described and now have to be validated. This review will give an overview of traditional and novel tools for the detection of drug induced cellular damage.
- Subjects
NICOTINAMIDE adenine dinucleotide phosphate; INTENSIVE care patients; BIOMARKERS; GLUTATHIONE peroxidase; ACUTE kidney failure
- Publication
International Journal of Pharmacy & Life Sciences, 2020, Vol 11, Issue 7, p56
- ISSN
0976-7126
- Publication type
Article