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- Title
A review on different techniques used for solubility enhancement poorly water soluble drugs.
- Authors
Sharma, Pravin Kumar; Darwhekar, Gajanan N.; Sharma, Pankaj K.; Shrivastava, Birendra
- Abstract
Solubility of drug plays major role in the process of formulation development. Solubility is the amount of solute that goes in to the solvent to form solution at given conditions of temperature, pressure and pH. Low aqueous solubility is the major problem associated with poorly water soluble drugs. Water is always the solvent of choice for liquid pharmaceuticals formulations. Most of the drugs are weakly acidic or weakly basic with poor aqueous solubility. About 40% of the drugs from newly developed chemical entities currently being discovered are poorly water soluble. The biopharmaceutical classification system of drugs suggests low water solubility, poor dissolution, and low bioavailability of Class II and IV drugs. This review article explain the various techniques used to enhance solubility of poorly water soluble drugs such as complexation of drugs, use of cosolvents, preparation of polymeric fast dissolving film, solid dispersion techniques, polymeric micelles, emulsion formation, polymeric micelles, microemulsions, pharmaceutical salts, nanomorph technology, pro-drugs, particle size reduction technologies.
- Subjects
DRUG solubility; DRUG development; SOLUTIONS (Pharmacy); SIZE reduction of materials; AQUEOUS solutions; BIOPHARMACEUTICS
- Publication
International Journal of Pharmacy & Life Sciences, 2017, Vol 8, Issue 12, p5679
- ISSN
0976-7126
- Publication type
Article