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- Title
Effects of aerobic exercise on cardiac function and gene expression of NADPH oxidases in diaphragm muscle of rats with aortic stenosis-induced heart failure.
- Authors
Gomes, Mariana Janini; Sabela, Ana Karenina; Pecin Ferreira, Isabele Tiburcio; Borges de Souza, Sérgio Luiz; Ferreira Mota, Gustavo Augusto; da Silva, Vitor Loureiro; Salomé de Campos, Dijon Henrique; Ruiz Lima, Aline Regina; Carvalho, Marianna Rabelo; Zanati Bazan, Silmeia Garcia; Corrêa, Camila Renata; Cicogna, Antônio Carlos; Okoshi, Marina Politi; Pacagnelli, Francis Lopes
- Abstract
We evaluated the influence of aerobic physical exercise (EX) on gene-encoding proteins associated with oxidative stress in diaphragm muscle of rats with aortic stenosis-induced heart failure (HF). Wistar male rats were divided into four groups: Control sedentary (C); Control exercise (C-Ex); Sedentary aortic stenosis (AS); Aortic stenosis exercise (AS-Ex). Exercised rats trained 5 times a week for 10 weeks on a treadmill. Statistical analysis was performed by ANOVA or Kruskal–Wallis test. In the final echocardiogram, animals with aortic stenosis subjected to exercise demonstrated improvement in systolic function compared to the sedentary aortic stenosis group. In diaphragm muscle, the activity of antioxidant enzymes, malondialdehyde malondialdehyde concentration, protein carbonylation, and protein expression of p65 and its inhibitor IκB did not differ between groups. Alterations in gene expression of sources that generate reactive species of oxygen were observed in AS-Ex group, which showed decreased mRNA abundance of NOX2 and NOX4 compared to the aortic stenosis group (p < 0.05). We concluded that aerobic exercise has a positive impact during heart failure, ameliorating systolic dysfunction and biomarkers of oxidative stress in diaphragm muscle of rats with aortic stenosis-induced heart failure.
- Subjects
AEROBIC exercises; HEART failure; GENE expression; AORTIC stenosis; OXIDASES; AORTIC valve transplantation; RESPIRATORY muscles
- Publication
Frontiers in Physiology, 2023, p1
- ISSN
1664-042X
- Publication type
Article
- DOI
10.3389/fphys.2023.1182303