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- Title
The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway.
- Authors
Zhenke Wen; Yi Shen; Berry, Gerald; Shahram, Farhad; Yinyin Li; Ryu Watanabe; Liao, Yaping Joyce; Goronzy, Jörg J.; Weyand, Cornelia M.
- Abstract
The article discusses the role of microvascular networks in the adventitia of large arteries. It mentions that the networks control access of inflammatory cells to the inner wall layers and protect the immune privilege of the aorta and its major branches. It notes the adventitial microvascular endothelial cells that perform immunoregulatory functions by up-regulating the expression of the Notch ligand Jagged.
- Subjects
T cells; LYMPHOCYTES; CELL membranes; MICROVASCULAR angina; GENE expression
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 399, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aal3322