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- Title
Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma.
- Authors
Oricchio, Elisa; Katanayeva, Natalya; Donaldson, Maria Christine; Sungalee, Stephanie; Joyce, Pasion P.; Béguelin, Wendy; Battistello, Elena; Sanghvi, Viraj R.; Man Jiang; Yanwen Jiang; Teater, Matt; Parmigiani, Anita; Budanov, Andrei V.; Fong Chun Chan; Shah, Sohrab P.; Kridel, Robert; Melnick, Ari M.; Ciriello, Giovanni; Wendel, Hans-Guido
- Abstract
The article explores on the role of sestrins or p53-regulated protein in the cellular response of the body to tumor development. It examines the translation of messenger RNA (mRNA) through the transcription of DNA under genotoxic stress. It also cites the treatment response of follicular lymphoma (FL).
- Subjects
PROTEINS; MESSENGER RNA; GENETIC toxicology; DNA; ESTRONE
- Publication
Science Translational Medicine, 2017, Vol 9, Issue 396, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aak9969