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- Title
Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy.
- Authors
Polanco, Maria Josè; Parodi, Sara; Piol, Diana; Stack, Conor; Chivet, Mathilde; Contestabile, Andrea; Miranda, Helen C.; Lievens, Patricia M.-J.; Espinoza, Stefano; Jochum, Tobias; Rocchi, Anna; Grunseich, Christopher; Gainetdinov, Raul R.; Cato, Andrew C. B.; Lieberman, Andrew P.; La Spada, Albert R.; Sambataro, Fabio; Fischbeck, Kenneth H.; Gozes, Illana; Pennuto, Maria
- Abstract
This article presents a study on the development of a strategy to reduce polyglutamine-androgen receptor(AR) (polyQ-AR) accumulation and toxicity in degenerating cells by modulation of the AR phosphorylation state. It discusses a decrease in the accumulation of phosphorylated AR in neuronal cells by adenylyl cyclase/protein kinase A signaling pathway, and the effect of phosphorylation on aggregation and turnover of polyQ-AR.
- Subjects
POLYGLUTAMINE; ANDROGEN receptors; PHOSPHORYLATION; PROTEIN kinases; JAK-STAT pathway
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 370, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaf9526