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- Title
NAD<sup>+</sup> repletion improves muscle function in muscular dystrophy and counters global PARylation.
- Authors
Dongryeol Ryu; Hongbo Zhang; Ropelle, Eduardo R.; Sorrentino, Vincenzo; Mázala, Davi A. G.; Mouchiroud, Laurent; Marshall, Philip L.; Campbell, Matthew D.; Ali, Amir Safi; Knowels, Gary M.; Bellemin, Stéphanie; Iyer, Shama R.; Xu Wang; Gariani, Karim; Sauve, Anthony A.; Cantó, Carles; Conley, Kevin E.; Walter, Ludivine; Lovering, Richard M.; Chin, Eva R.
- Abstract
The article discusses a study which found that nicotinamide adenine dinucleotide (NAD+) repletion is effective in improving muscle function in neuromuscular diseases like Duchene's muscular dystrophy (DMD) and delay both age-related and mdx muscle stem cell senescence. In the mice study, the correlations between the abundance of messenger ribonucleic acid (mRNA) transcripts related to mitochondrial biogenesis, the dystrophin-sarcoglycan complex, and NAD+ were observed.
- Subjects
DUCHENNE muscular dystrophy; NAD (Coenzyme); NEUROMUSCULAR diseases; LABORATORY rats; STEM cells; MESSENGER RNA
- Publication
Science Translational Medicine, 2016, Vol 8, Issue 361, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaf5504