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- Title
Allergic Reactions to Oxaliplatin in a Single Institute in Japan.
- Authors
Ichikawa, Yasushi; Goto, Ayumu; Hirokawa, Satoru; Kijima, Miyuki; Ishikawa, Takashi; Chishima, Takashi; Suwa, Hirokazu; Yamamoto, Harumi; Yamagishi, Shigeru; Osada, Shunichi; Ota, Mitsuyoshi; Fujii, Shoichi
- Abstract
Allergic reactions to oxaliplatin can be severe and are an important cause of discontinuation of treatment. A retrospective review was performed for 105 patients who received FOLFOX regimens between May 2005 and June 2007. Twenty-five cases (23.8%) of allergic reactions were identified, including 9 late onset reactions (8.6%) and 16 immediate reactions (15.2%). Severe allergy (Grades 3 and 4) occurred in seven patients (6.7%). Re-introduction of FOLFOX was attempted for seven immediate onset patients with a severity grade of 1 or 2, and three of these patients (42.9%) showed relapse of allergy. In ∼10% of the patients, FOLFOX had to be discontinued due to allergy before the disease became refractory to the regimen. Our experience indicates that allergy to oxaliplatin may be a significant concern and that methods are required for suppression of this allergy.
- Publication
Japanese Journal of Clinical Oncology, 2009, Vol 39, Issue 9, p616
- ISSN
0368-2811
- Publication type
Article
- DOI
10.1093/jjco/hyp070