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- Title
A magnetic resonance (MR) compatible selective brain temperature manipulation system for preclinical study.
- Authors
Qingwei Liu; Yu Cai; Weili Lin; Turner, Gregory H.; Hongyu An
- Abstract
There is overwhelming evidence that hypothermia can improve the outcome of an ischemic stroke. However, the most widely used systemic cooling method could lead to multiple side effects, while the incompatibility with magnetic resonance imaging of the present selective cooling methods highly limit their application in preclinical studies. In this study, we developed a magnetic resonance compatible selective brain temperature manipulation system for small animals, which can regulate brain temperature quickly and accurately for a desired period of time, while maintaining the normal body physiological conditions. This device was utilized to examine the relationship between T1 relaxation, cerebral blood flow, and temperature in brain tissue during magnetic resonance imaging of ischemic stroke. The results showed that this device can be an efficient brain temperature manipulation tool for preclinical studies needing local hypothermic or hyperthermic conditions
- Subjects
HYPOTHERMIA; ISCHEMIA; BODY temperature; MAGNETIC resonance imaging; BLOOD circulation
- Publication
Medical Devices: Evidence & Research, 2012, Vol 5, p13
- ISSN
1179-1470
- Publication type
Article
- DOI
10.2147/MDER.S26835