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- Title
Brief Report: Association Between Autism Spectrum Disorder, Gastrointestinal Problems and Perinatal Risk Factors Within Sibling Pairs.
- Authors
Isaksson, Johan; Pettersson, Erik; Kostrzewa, Elzbieta; Diaz Heijtz, Rochellys; Bölte, Sven
- Abstract
Autism spectrum disorder (ASD) has been associated with gastrointestinal (GI) problems, but the nature of this association is unclear. Parents to siblings, concordant or discordant for ASD ( N = 217), participated in a web survey covering mother's weight gain during pregnancy, maternal viral/bacterial infection and use of antibiotics, duration of breastfeeding, mode of delivery, birth weight and child GI problems. ASD was associated with GI problems and perinatal environmental risk, based on a summation of maternal infection and antibiotic use during pregnancy and/or the breastfeeding period. The association between GI problems and ASD remained within the sibling pairs ( β = 1.23; p < .001) in the adjusted model. Our results indicate non-shared environmental effects on the ASD/GI association, but none of the factors examined explained the link.
- Subjects
GASTROINTESTINAL diseases; AUTISM risk factors; ANTIBIOTICS; BREASTFEEDING; SIBLINGS; ECOLOGY; INFECTION; PARENTS; RISK assessment; SURVEYS; DISEASE complications; DISEASE risk factors
- Publication
Journal of Autism & Developmental Disorders, 2017, Vol 47, Issue 8, p2621
- ISSN
0162-3257
- Publication type
Report
- DOI
10.1007/s10803-017-3169-2