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- Title
Association Between BRAFV6OOE Mutation and Mortality in Patients With Papillary Thyroid Cancer.
- Authors
Mingzhao Xing; Alzahrani, Ali S.; Carson, Kathryn A.; Viola, David; Elisei, Rossella; Bendlova, Bela; Yip, Linwah; Mian, Caterina; Vianello, Federica; Tuttle, R. Michael; Robenshtok, Eyal; Fagin, James A.; Puxeddu, Efisio; Fugazzola, Laura; Czarniecka, Agnieszka; Jarzab, Barbara; O'Neill, Christine J.; Sywak, Mark S.; Lam, Alfred K.; Riesco-Eizaguirre, Garcilaso
- Abstract
The article discusses research which investigated the relationship between BRAF V600E mutation and papillary thyroid cancer (PTC)-related mortality. BRAF V600E is a prominent oncogene in PTC. A total of 1,849 patients with a median age of 46 years are considered in the study. Findings revealed 5.3% mortality in BRAF-positive versus mutation-negative patients. Deaths per 1000 person-years in the analysis of PTC conventional variant were 11.80 versus 2.25 in BRAF-positive versus mutation-negative patients. A higher BRAF-associated mortality was observed in clinicopathological subcategories.
- Subjects
GENETIC mutation; THYROID cancer; CANCER-related mortality; ONCOGENES; DEATH rate; PATHOLOGICAL physiology; GENETICS
- Publication
JAMA: Journal of the American Medical Association, 2013, Vol 309, Issue 14, p1493
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.2013.3190