We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Age- and sex-specific reference limits for creatinine, cystatin C and the estimated glomerular filtration rate.
- Authors
Hannemann, Anke; Friedrich, Nele; Dittmann, Kathleen; Spielhagen, Christin; Wallaschofski, Henri; Völzke, Henry; Rettig, Rainer; Endlich, Karlhans; Lendeckel, Uwe; Stracke, Sylvia; Nauck, Matthias
- Abstract
Background: Early detection of patients with chronic kidney disease is of great importance. This study developed reference limits for serum creatinine and serum cystatin C concentrations and for the estimated glomerular filtration rate (eGFR) in healthy subjects from the general population aged 25-65 years. Methods: This study defined a reference population including 985 subjects from the first follow-up of the Study of Health in Pomerania. Serum creatinine was measured with a modified kinetic Jaffé method. Serum cystatin C was measured with a nephelometric assay. The eGFR was calculated from serum creatinine according to the Cockcroft-Gault (eGFRCG) and the Modification of Diet in Renal Disease (eGFRMDRD) equation, respectively, as well as from serum cystatin C according to the formula by Larsson (eGFRLarsson). Non-parametric quantile regression was used to estimate the reference limits. For serum creatinine and serum cystatin C the 95th percentile and for eGFRCG, eGFRMDRD and eGFRLarsson the 5th percentile were selected as reference limits. All data was weighted to reflect the age- and sex-structure of the German population in 2008. Results: The reference limits for serum creatinine (men: 1.11-1.23 mg/dL; women: 0.93-1.00 mg/dL) and serum cystatin C levels (men: 0.92-1.04 mg/L; women: 0.84-1.02 mg/L) increased with advancing age. The reference limits for eGFR decreased with increasing age (eGFRCG men: 106.0-64.7 mL/min, women 84.4-57.9 mL/min; eGFRMDRD men: 82.5-62.2 mL/min/1.73 m2, women 75.0-58.2 mL/min/1.73 m2; eGFRLarsson men: 85.5-72.9 mL/min, women 94.5-75.7 mL/min). Conclusions: This study presents age- and sex-specific reference limits for five measures of renal function based on quantile regression models.
- Subjects
CREATININE; CYSTATINS; GLOMERULAR filtration rate; KIDNEY diseases; OLD age
- Publication
Clinical Chemistry & Laboratory Medicine, 2012, Vol 50, Issue 5, p919
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm.2011.788