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- Title
Inflammation Markers and Metabo Characteristics of Subjects With 1-h Plasma Glucose Levels.
- Authors
Bardini, Gianluca; Dicembrini, Ilaria; Cresci, Barbara; Rotella, Carlo Maria
- Abstract
OBJECTIVE -- To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes. RESEARCH DESIGN AND METHODS -- A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and below the 1hPG cut point (155 mg/dl). Fibrinogen and leukocytes count (white blood cells [WBCs]) for subclinical inflammation, lipid ratios, insulin sensitivity (Matsuda index) were determined. RESULTS -- Patients with NGT and pre-diabetes (1hPG > 155 mg/dl) showed a significant increase of inflammatory markers and lipid ratios (for all, P < 0.05). In age-, sex-, and BMI-adjusted analysis, 1hPG was associated with a significantly higher WBC count and fibrinogen (P < 0.05). Patients with elevated 1hPG showed a highly significant lower insulin sensitivity than subjects <1hPG (P < 0.01). CONCLUSIONS -- Elevated 1hPG in subjects with NGT and pre-diabetes is associated with subclinical inflammation, high lipid ratios, and insulin resistance. Therefore, 1hPG > 155 mg/dl could be considered a new "marker" for cardiovascular risk.
- Subjects
INFLAMMATION; LIPID metabolism; BLOOD sugar; DIABETES; FIBRINOGEN; LEUCOCYTES; INSULIN resistance; GLUCOSE tolerance tests
- Publication
Diabetes Care, 2010, Vol 33, Issue 2, p411
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc09-1342