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- Title
Plak tip psoriasis tedavisinde asitretin ve dar bant UVB ile plasebo ve dar bant UVB kombinasyonunun karşılaştırıldığı tek kör çalışma.
- Authors
Gürel, Gülhan; Saraçoğlu, Zeynep Nurhan; Aksu, Ayşe Esra Koku
- Abstract
Background and Design: In this study, we aimed to compare the effects of the combination of acitretin and narrow-band UVB with the combination of placebo and narrow-band UVB in the treatment of plaque-type psoriasis. Materials and Methods: A total of 50 patients with plaque-type psoriasis, in whom more than 10% of the body surface area was affected, were divided into 2 groups of 25 subjects. The first group was treated with narrow-band UVB and 25 mg/day oral acitretin and the second group was treated with narrow-band UVB and placebo. The patients were evaluated every 2 weeks during a 12 week-period. In each patient visit, psoriasis area severity index (PASI) scores were evaluated by an independent observer. Self-administered PASI (SAPASI) scores were calculated. Pre- and post-treatment quality of life was evaluated using the Skindex 29. Results: The study included a total of 50 patients (25 female, 25 male) aged 18-71 years. When PASI and SAPASI changes were evaluated, there were significant differences between the two groups at second week (p<0.05). In addition, there were significant differences between the two groups in terms of PASI and SAPASI values at 4th, 6th, 8th, 10th and 12th weeks (p<0.001). Clinical response was found to be better in patients treated with the combination of acitretin and narrow-band UVB compared to those treated with narrow-band UVB therapy alone. Both treatment protocols were found to lead to significant improvement in the scores of the symptoms, function and emotional scales of Skindex 29. Conclusion: Because of short and better response to combination treatment, clinicians may prefer combination treatment for patients who have psoriasis vulgaris and are suitable for taking narrow-band UVB and acitretin. Psoriasis is considered as a kind of disease that has significant impacts on quality of life.
- Subjects
PSORIASIS treatment; COMPARATIVE studies; ORAL drug administration; PLACEBOS; QUALITY of life; MEDICAL radiology; RETINOIDS; ULTRAVIOLET radiation; BLIND experiment; THERAPEUTICS
- Publication
Archives of the Turkish Dermatology & Venerology / Turkderm, 2015, Vol 49, Issue 1, p2
- ISSN
1019-214X
- Publication type
Article
- DOI
10.4274/turkderm.54771