We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis and physicochemical characterization of rhamnolipid fabricated fucoxanthin loaded bovine serum albumin nanoparticles supported by simulation studies.
- Authors
Jaiswal, Jyoti; Srivastav, Amit Kumar; Patel, Rahul; Kumar, Umesh
- Abstract
BACKGROUND: Fucoxanthin is a hydrophobic carotenoid with many beneficial biological activities. However, due to low aqueous solubility their clinical efficacy is limited thus leading to poor oral bioavailability. To address this issue, we encapsulated fucoxanthin in rhamnolipid fabricated bovine serum albumin (BSA) loaded nanoparticles (LNPs) for improving solubility dependent bioavailability of fucoxanthin. RESULTS: These synthesized LNPs were characterized by dynamic light scattering (DLS), ultraviolet (UV)‐visible spectrophotometry, high‐performance liquid chromatography (HPLC), Fourier‐transform infrared (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC). Our results showed that LNPs were spherical in shape with particle size around 180 nm along with positive zeta potential. The encapsulation efficiency and loading efficiency calculated for LNPs were 69.66 ± 1.5% and 14 ± 0.2%, respectively. The antioxidant assay of LNPs indicate high radical scavenging activity compared to pure fucoxanthin. Besides this, our release studies indicates that drug release occur from the matrix of nanocarrier system through diffusion based on concentration. Thus, these findings indicate successful encapsulation of fucoxanthin, with improved solubility thereby leading to increased bioavailability. This nano formulation is derived from components which are FDA approved that could be exploited for encapsulating other vital nutraceutical molecules. CONCLUSION: Overall, our results showed successful synthesis of biodegradable nanocarrier for delivering fucoxanthin supported by molecular docking, molecular dynamics simulation and thermodynamics of free binding energy studies. © 2022 Society of Chemical Industry.
- Subjects
SOCIETY of Chemical Industry (Great Britain); UNITED States. Food &; Drug Administration; SERUM albumin; RHAMNOLIPIDS; FREE energy (Thermodynamics); MOLECULAR dynamics; HIGH performance liquid chromatography; BOS
- Publication
Journal of the Science of Food & Agriculture, 2022, Vol 102, Issue 12, p5468
- ISSN
0022-5142
- Publication type
Article
- DOI
10.1002/jsfa.11901