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- Title
Researches Regarding the Residue Levels of 17β-Estradiol in Blood, Urine and Muscle in Prepuberal Sheep and their Influence on Follicular Pool.
- Authors
Radu, Ionel; Miclăuş, Viorel; Pop, Alexandru Raul; Rus, Vasile; Groza, Ioan
- Abstract
Studies were made on a number of 35 prepuberal Merinos cross breed female sheep, three months age, equally divided in three experimental groups and one control group. Females in the experimental groups were given 0.2 ml/animal (2.5 mg/ml) hexoestrol diacetate, intramuscularly. After 30, 60, 90 and 120 days respectively, blood, urine, muscle tissue (by biopsy) samples were harvested in order to determine, through electrochemioiluminescence, tie concentrations of the residue of this steroidal compound. Ovaries were also harvested through ovarioectomy for histo-pathological examination. The maximum levels of this hormone residue were identified in urine (the average value being 652,4 pgfail, for group I), intermediate values in blood samples (43.74 pg/ml), while the muscle samples revealed concentrations inferior to the detection limit for the utilized method (18.4 pg/g). Atretic follicles were present in very large numbers, and the primordial follicle pool was reduced by over 50% in the ovaries harvested from the experimental grcup. We can see that the hexestrol diacetate initiates and maintains the follicular atresia in young prepuberal female sheep, with drastic reduction of the follicle pool, compromising the female reproductively.
- Subjects
SHEEP breeding; SHEEP farming; HEALTH of sheep; HORMONES; SECRETION
- Publication
Bulletin of the University of Agricultural Sciences & Veterinary Medicine Cluj-Napoca. Veterinary Medicine, 2012, Vol 69, Issue 1/2, p422
- ISSN
1843-5270
- Publication type
Article