We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparison of the acute-phase response after laparoscopic versus open aortobifemoral bypass surgery: a substudy of a randomized controlled trial.
- Authors
Krog, Anne H.; Sahba, Mehdi; Pettersen, Erik M.; Sandven, Irene; Thorsby, Per M.; Jørgensen, Jørgen J.; Sundhagen, Jon O.; Kazmi, Syed S. S.; Kazmi, Syed Ss
- Abstract
<bold>Purpose: </bold>Minimally invasive surgical techniques have been shown to reduce the inflammatory response related to a surgical procedure. The main objective of our study was to measure the inflammatory response in patients undergoing a totally laparoscopic versus open aortobifemoral bypass surgery. This is the first randomized trial on subjects in this population.<bold>Patients and Methods: </bold>This is a substudy of a larger randomized controlled multicenter trial (Norwegian Laparoscopic Aortic Surgery Trial). Thirty consecutive patients with severe aortoiliac occlusive disease eligible for aortobifemoral bypass surgery were randomized to either a totally laparoscopic (n=14) or an open surgical procedure (n=16). The inflammatory response was measured by perioperative monitoring of serum interleukin-6 (IL-6), IL-8, and C-reactive protein (CRP) at six different time points.<bold>Results: </bold>The inflammatory reaction caused by the laparoscopic procedure was reduced compared with open surgery. IL-6 was significantly lower after the laparoscopic procedure, measured by comparing area under the curve (AUC), and after adjusting for the confounding effect of coronary heart disease (P=0.010). The differences in serum levels of IL-8 and CRP did not reach statistical significance.<bold>Conclusion: </bold>In this substudy of a randomized controlled trial comparing laparoscopic and open aortobifemoral bypass surgeries, we found a decreased perioperative inflammatory response after the laparoscopic procedure measured by comparing AUC for serum IL-6.
- Subjects
ACUTE phase reaction; ENDOSCOPIC surgery; LAPAROSCOPIC surgery; RANDOMIZED controlled trials; IMMUNE response; C-reactive protein
- Publication
Vascular Health & Risk Management, 2016, Vol 12, p371
- ISSN
1176-6344
- Publication type
journal article
- DOI
10.2147/VHRM.S110600