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- Title
Seven-Year Follow-up of Matrix-Induced Autologous Implantation in Talus Articular Defects.
- Authors
Kreulen, Christopher; Giza, Eric; Walton, Judie; Sullivan, Martin
- Abstract
<bold>Background: </bold>Osteochondral lesions of the talus (OLT) are difficult to treat because of the poor intrinsic healing capability of articular cartilage. Matrix-induced autologous chondrocyte implantation (MACI) has been shown to be a reliable method for treating cartilage lesions that fail to respond to traditional microfracture and debridement. The purpose of this study was to assess 7-year clinical follow-up data of this technique and demonstrate midterm success of this implant.<bold>Methods: </bold>A prospective investigation of MACI was performed on 10 patients with OLTs who had failed previous arthroscopic treatment. In all, 5 male and 5 female patients were included in the study. Of the 10 patients, 9 were available for 7-year follow-up. Functional and clinical evaluations were done at 7 years postoperatively using the American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot evaluation and the Short Form Health Survey (SF-36) and compared with preoperative values.<bold>Results: </bold>SF-36 data at 7 years showed significant improvements in Physical Functioning (P < .01), Lack of Bodily Pain (P < .1), and Social Functioning (P < .001) compared with preoperative data. The mean AOFAS hindfoot scores of the 9 patients at 7 years was 78.3 ± 18.1 (P = .05) compared with their preoperative mean of 61.8 ± 14.3.<bold>Conclusions: </bold>MACI provides a stable midterm chondral replacement strategy for osteochondral lesions that fail initial microfracture.<bold>Levels Of Evidence: </bold>Level IV: Prospective case series.
- Subjects
ANKLE surgery; CARTILAGE cell transplantation; ARTICULAR cartilage; ANKLEBONE surgery; ANKLE; ANKLEBONE; ARTHROSCOPY; AUTOGRAFTS; HEALTH surveys; LONGITUDINAL method; QUESTIONNAIRES; TIME; TISSUE engineering; TREATMENT effectiveness; SURGERY
- Publication
Foot & Ankle Specialist, 2018, Vol 11, Issue 2, p133
- ISSN
1938-6400
- Publication type
journal article
- DOI
10.1177/1938640017713614