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- Title
Hypoxia Increases Serum Amyloid A3 (SAA3) in Differentiated 3T3-L1 Adipocytes.
- Authors
Oliveira, Edson; Sandri, Silvana; Knebel, Franciele; Contesini, Caroline; Campa, Ana; Filippin-Monteiro, Fabíola
- Abstract
Hypoxia has been implicated as a possible cause of adipose tissue inflammation. Furthermore, the acute phase protein serum amyloid A (SAA) has been associated with the modulation of the adipogenic process, and it is well-known that obese individuals have increased levels of SAA. The effect of hypoxia in the expression and production of SAA was examined in murine 3T3-L1 adipocytes. Hypoxia leads to a substantial increase in SAA3 mRNA and protein level, apparently in a time-dependent manner (threefold in 48 h), in fully differentiated 3T3-L1, followed by reestablishment of gene expression to basal levels after 24 h of reoxygenation. Hypoxia-induced SAA may be one of the key molecules to the development of the inflammatory response in adipose tissue.
- Subjects
HYPOXEMIA; ADIPOSE tissues; AMYLOID; GENE expression; INFLAMMATION; FAT cells; LABORATORY mice
- Publication
Inflammation, 2013, Vol 36, Issue 5, p1107
- ISSN
0360-3997
- Publication type
Article
- DOI
10.1007/s10753-013-9644-9