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- Title
Mechanochemical C−X/C−H Functionalization: An Alternative Strategic Access to Pharmaceuticals.
- Authors
Yang, Xinjie; Wu, Chongyang; Su, Weike; Yu, Jingbo
- Abstract
In the pursuit of clean pharmaceutical production, chemists in medicinal industry require access to new sustainable methodologies to reduce and even eliminate pollution, which is mainly produced by the overuse of organic solvents during chemical synthesis of active pharmaceutical ingredients (APIs). In this context, the solvent‐free/less mechanochemical functionalization of small molecules has gradually emerged as a powerful strategy for the green synthesis and modification of APIs, bioactive compounds, and functional materials. In this review, we present an overview of mechanochemical C−X/C−H functionalization applications to medicinal chemistry, involving cross‐coupling, cross‐dehydrogenative coupling, oxidative coupling (via C−H activation pathway), and direct coupling (via radical pathway) as key steps for the preparation of APIs and bioactive compounds.
- Subjects
PHARMACEUTICAL chemistry; CHEMICAL synthesis; BIOACTIVE compounds; GREEN business; CHEMISTS; OXIDATIVE coupling
- Publication
European Journal of Organic Chemistry, 2022, Vol 2022, Issue 8, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202101440