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- Title
Treating Progressive Multifocal Leukoencephalopathy With Interleukin 7 and Vaccination With JC Virus Capsid Protein VP1.
- Authors
Sospedra, Mireia; Schippling, Sven; Yousef, Sara; Jelcic, Ilijas; Bofill-Mas, Silvia; Planas, Raquel; Stellmann, Jan-Patrick; Demina, Viktoria; Cinque, Paola; Garcea, Robert; Croughs, Therese; Girones, Rosina; Martin, Roland
- Abstract
Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well tolerated, and showed a very favorable safety profile and unexpected efficacy that warrant further investigation.
- Subjects
PROGRESSIVE multifocal leukoencephalopathy; INTERLEUKIN-1; TOLL-like receptors; INTERLEUKINS; DRUG efficacy; THERAPEUTICS
- Publication
Clinical Infectious Diseases, 2014, Vol 59, Issue 11, p1588
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciu682