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- Title
Association of Single-Nucleotide Polymorphism 3 and c.553G1T of APOA5 with Hypertriglyceridemia after Treatment with Highly Active Antiretroviral Therapy Containing Protease Inhibitors in HIV-Infected Individuals in Taiwan.
- Authors
Sui-Yuan Chang; Wei-Shin Ko; Jau-Tsuen Kao; Lan-Yang Chang; Hsin-Yun Sun; Mao-Yuan Chen; Szu-Min Hsieh; Wang-Huei Sheng; Shu-Fang Chang; Wen-Chun Liu; Cheng-Hsin Wu; Hui-Jen Hsu; Chuan-Liang Kao; Chun-Nan Lee; Chien-Ching Hung; Shan-Chwen Chang
- Abstract
We investigated the relationship between hypertriglyceridemia and the single-nucleotide polymorphisms (SNPs) on APOA5 in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) in Taiwan. Receipt of protease inhibitor-based HAART, high baseline triglyceride levels, and carriage of APOA5 SNP3 or c.553G>T variants or APOA5 SNP1T/SNP2G/SNP3C/c.553T haplotype were statistically significantly associated with development of extreme hypertriglyceridemia (triglyceride level, >500 mg/dL).
- Subjects
TAIWAN; HYPERTRIGLYCERIDEMIA; GENETIC polymorphisms; HIV-positive persons; HIGHLY active antiretroviral therapy; ANTIVIRAL agents; THERAPEUTICS; PROTEASE inhibitors; TRIGLYCERIDES
- Publication
Clinical Infectious Diseases, 2009, Vol 48, Issue 6, p832
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/597099