We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Side-effects of antipsychotic medication and health-related quality of life in schizophrenia.
- Authors
Bebbington, P. E.; Angermeyer, M.; Azorin, J.‐M.; Marwaha, S.; Marteau, F.; Toumi, M.
- Abstract
Objective: This analysis used data from the large ( n = 1208) European Schizophrenia Cohort to examine the association between subjective side-effects of antipsychotic medication and the Mental and Physical Composite Scores (MCS; PCS) of the SF-36 scale. Method: Relationships between the subjective evaluation of side-effects identified from the Subjective Side-Effects Scale and the adjusted mean score on the PCS and MCS were examined. Where appropriate, these associations of subjective side-effects were compared with those of the same side-effects measured objectively. Results: In this study, subjective side-effects of antipsychotic medication were linked either to both the PCS and the MCS or, in a few instances, to neither. Subjective evaluations of sexual side-effects were associated only with the MCS, those of sialorrhoea only with the PCS. Objective ratings of extrapyramidal side-effects were related neither to PCS nor to MCS. Conclusion: These data suggest that side-effects, whether subjective or objective, may need to be considered individually in relation to their impact on quality of life.
- Subjects
SCHIZOPHRENIA treatment; ANTIPSYCHOTIC agents; PHARMACOLOGY; MENTAL illness; QUALITY of life
- Publication
Acta Psychiatrica Scandinavica, 2009, Vol 119, p22
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1111/j.1600-0447.2008.01310.x