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- Title
Protective Effect of Ipragliflozin in Acute Brain Injury Induced by Endotoxemia in Mice.
- Abstract
Aims: This study was done to investigate the potential neuroprotective effect of ipragliflozin during endotoxemia in mice. Materials & Methods: 24 adult male Swiss-albino mice aged 8-12 weeks, with a weight of 25-35gram, were randomized into 4 equal groups (n=6), sham (Laparotomy without cecal ligation and puncture (CLP), sepsis (Laparotomy with CLP), vehicle (Equivalent volume of DMSO prior to CLP), ipragliflozin (3mg/kg/day, orally prior to CLP). Brain is used to assess tissue TNF-α, IL-6, IL-1α, TLR4, and P-STAT3, as well as the histological examination. Findings: The outcomes of this experimental investigation revealed that tissue values of TNF-α, IL-6, and IL-1B are much lower in the sham group than in the sepsis and vehicle groups. Furthermore, the ipragliflozin group had considerably lower tissue values of TNF-α, IL-6, and IL-1B than the sepsis and vehicle groups; The sham group, on the other hand, had much lower tissue values of TLR4, and STAT3 than the sepsis and vehicle groups. Furthermore, it was discovered that the tissue levels of TLR4, and STAT3 in the ipragliflozin group were considerably lower than those in the sepsis and vehicle groups. Histopathology analysis demonstrated that ipragliflozin might considerably reduce brain damage when compared to sepsis and vehicle groups that showed interstitial edema and presence of glial cells with pyknotic nuclei. Conclusion: Ipragliflozin could attenuate brain dysfunction during CLP-induced polymicrobial sepsis in male mice.
- Subjects
ENDOTOXEMIA; INTERLEUKINS; STAT proteins; MATHEMATICAL statistics; NONPARAMETRIC statistics; PARAMETERS (Statistics); ANIMAL experimentation; ONE-way analysis of variance; RISK assessment; NEUROPROTECTIVE agents; TUMOR necrosis factors; DESCRIPTIVE statistics; CHI-squared test; BRAIN injuries; STATISTICAL sampling; DATA analysis software; ACUTE diseases; MICE; DISEASE risk factors; DISEASE complications
- Publication
Iranian Journal of War & Public Health, 2023, Vol 15, Issue 3, p1
- ISSN
2008-2622
- Publication type
Article
- DOI
10.58209/ijwph.15.3.225