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- Title
The secret life of kinases: insights into noncatalytic signalling functions from pseudokinases.
- Authors
Jacobsen, Annette V.; Murphy, James M.
- Abstract
Over the past decade, our understanding of the mechanisms by which pseudokinases, which comprise ~10% of the human and mouse kinomes, mediate signal transduction has advanced rapidly with increasing structural, biochemical, cellular and genetic studies. Pseudokinases are the catalytically defective counterparts of conventional, active protein kinases and have been attributed functions as protein interaction domains acting variously as allosteric modulators of conventional protein kinases and other enzymes, as regulators of protein trafficking or localisation, as hubs to nucleate assembly of signalling complexes, and as transmembrane effectors of such functions. Here, by categorising mammalian pseudokinases based on their known functions, we illustrate the mechanistic diversity among these proteins, which can be viewed as a window into understanding the non-catalytic functions that can be exerted by conventional protein kinases.
- Subjects
PROTEIN kinases; CELLULAR signal transduction; PROTEIN-protein interactions; MEMBRANE proteins; BIOCHEMISTRY
- Publication
Biochemical Society Transactions, 2017, Vol 45, Issue 3, p665
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20160331