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- Title
FBPase is in the nuclei of cardiomyocytes
- Authors
Gizak, A.; Dzugaj, A.
- Abstract
Intracellular localization of FBPase in the cardiac muscle of the pig was studied by immunohistochemistry. In contrast to data from skeletal muscle [Gizak, A., Rakus, D. and Dzugaj, A. (2003) Histol. Histopathol. 18, 135–142], in cardiomyocytes FBPase was present not only in the cytoplasm, but surprisingly, also in the nucleus. Results of the microscopic investigation were confirmed by immunoblotting, measurement of FBPase activity in isolated cardiomyocyte nuclei and by determination of the nuclear FBPase I0.5 toward adenosine monophosphate (AMP), which was the same as for the purified enzyme.
- Subjects
HEART cells; FRUCTOSE
- Publication
FEBS Letters, 2003, Vol 539, Issue 1-3, p51
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)00183-2