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- Title
The Structure and Release Kinetics of Ca–Al Layered Double Hydroxide by Intercalating with Diclofenac Sodium.
- Authors
Ma, Yingying; Zhang, Shuhua; Wang, Yu; Jiang, Zhenlin; Fu, Nengshuo; Yang, Zhuo; Mao, Yongjun
- Abstract
Diclofenac sodium (DS) is an aryl acetic acid nonsteroidal anti-inflammatory drug which is widely used in various types of chronic bone and joint pains, but its terminal plasma half life is short, often accompanied with gastrointestinal side effects. We try to find an inexpensive and effective drug carrier to prolong the administration interval, maintain a stable blood concentration and reduce side effects. In our work, DS had been intercalated into a layered inorganic host, Ca–Al layered double hydroxide (LDH) by co-precipitation under a nitrogen atmosphere to control the release. X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM) and transmission electron microscope (TEM) were used to investigate the change of chemical structure and morphological structure when DS was inserted into the interlayer of LDH. X-ray photoelectron spectroscopy (XPS) and X-ray absorption near edge structure (XANES) were employed to characterize the electron binding energy of calcium and aluminum cations both on the surface and in the bulk of the samples. The results of absorption peaks, morphologies and the basal spacing increased from 8.6 Å to 29.59 Å gave the evidences for the intercalation of DS into the interlayer of CaAl-LDH. The results of XPS and XANES spectra revealed the complexation of –OH and NO 3 − with Ca 2 + and Al 3 + were both were affected by the loading of DS with CaAl-LDH, but no new chemical bonds were formed. Inductively coupled plasma optical emission spectroscopy (ICP-OES) analysis showed the dissolving process of Ca and Al ions from CaAl-LDH in the solution. In addition, the results of the drug release profile and release kinetic of intercalated LDHs showed that release behavior of DS from intercalated compounds was well controlled. In this study, not only the sodium diclofenac (DS) intercalated CaAl-LDH denoted as CaAl-DS-LDH was successfully prepared, but also the XANES, TEM, etc. were used to analyze the effect on the microstructure of hydrotalcite after drug loading. The area of the diffraction ring had decreased in the CaAl-DS-LDH, indicating the DS intercalated reduced the crystallinity of CaAl-LDH. DS only affected the electron cloud around the element, whereas it did not form a new bond with CaAl-LDH.
- Subjects
CALCIUM ions; LAYERED double hydroxides; ALUMINUM-zinc alloys; INDUCTIVELY coupled plasma atomic emission spectrometry; X-ray absorption near edge structure; CHEMICAL bonds; DICLOFENAC; BINDING energy
- Publication
NANO, 2020, Vol 15, Issue 3, pN.PAG
- ISSN
1793-2920
- Publication type
Article
- DOI
10.1142/S1793292020500289