We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Związek sztywności tętnic z funkcją rozkurczową lewej komory serca w populacji ogólnej.
- Authors
WOJCIECHOWSKA, Wiktoria; STOLARZ-SKRZYPEK, Katarzyna; OLSZANECKA, Agnieszka; KAWECKA-JASZCZ, Kalina; CZARNECKA, Danuta
- Abstract
Left ventricular diastolic function declines with aging and hypertension. It is well known that elevated blood pressure results in increased arterial stiffness. The study aims to determine the relationship between arterial stiffness and left ventricular diastolic dysfunction in randomly recruited subjects from a general population. Design and methods: We recruited 303 (mean age, 46.9 years; 167 women; 155 normotensives) members of nuclear families. Normotension and hypertension were diagnosed based on both office and ambulatory blood pressure measurements, or history of antihypertensive treatment. Pulse wave velocity (PWV), peripheral and central pulse pressure (pPP; cPP) was evaluated by means of pulse wave analysis and oscillometric blood pressure measurements. Left ventricle (LV) diastolic function was determined by measuring transmitral early (E) and late (A) diastolic peak velocities and E/A ratio, diastolic velocities of septal and lateral mitral annulus (E' wave and E/E' ratio) obtained in tissue doppler and evaluation of left atrium diameter (LA). Results: After adjusting for relatedness, pPP, cPP and PWV were negatively associated with E/A, and positively with E/E' and LA (P <0.001). In multivariate analysis the most closely related parameters were cPP - E/E'(β=0.04, P=0.001), PWV- -E/E' (β=0.14, P=0.011), and pPP-E/E' (β=0.03, P=0.003). Additionally pPP and PWV was associated with LA diameter (β=0.04, P=0.012; and β=0.54, P=0.021, respectively). Moreover we observed higher risk of having a LV diatolic dysfunction with higher PWV (OR 0.65 (CI 0.55-0.87). Conclusion: Our study suggested that increased arterial stiffness as estimated by pulse pressure and pulse wave velocity measurement might be considered as a predictor of left ventricular diastolic dysfunction.
- Publication
Review of Medicine / Przeglad Lekarski, 2018, Vol 75, Issue 8, p394
- ISSN
0033-2240
- Publication type
Article