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- Title
Australia/SH Antigen: Application of Immunodiffusion and Complement Fixation Tests to a Consecutive Series of Patients with Acute and Chronic Viral Hepatitis.
- Authors
Hersh, Theodore; Sakurada, Norio; Melnick, Joseph L.
- Abstract
Australia/SH antigen was measured by immunodiffusion and complement fixation technics in a consecutive series of sera from hepatitis patients. These included 137 patients with acute viral hepatitis, 20 with chronic active hepatitis and eight with anicteric hepatitis. Fifty control subjects with other diseases of the liver also were tested. Sixty-six per cent of 73 patients with a diagnosis of serum hepatitis and 28 per cent of 64 patients with a diagnosis of infectious hepatitis were positive for the Au/SH antigen at the onset of the illness. In most cases, both serologic tests became negative as the icterus cleared and the serum transaminases returned to normal levels. In eight of these patients, only the complement fixation test was positive. Six of eight addicts with anicteric hepatitis and seven of 20 patients with chronic active hepatitis (35 per cent) were also positive for Au/SH antigen. Forty of the total group studied with viral hepatitis were addicts, and of these 21 were Au/SH antigen-positive. Anticomplementary activity was present in samples of 25 hepatitis patients whose immunodiffusion test for Au/SH antigen was negative and in four others whose immunodiffusion test was positive. Anticomplementary activity decreased in blood as the icterus developed and in some cases was again detected in the convalescent phase.
- Subjects
ANTIGENS; IMMUNODIFFUSION; COMPLEMENT fixation; HEPATITIS; PATIENTS; JAUNDICE
- Publication
American Journal of Gastroenterology (Springer Nature), 1972, Vol 57, Issue 2, p109
- ISSN
0002-9270
- Publication type
Article