We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance.
- Authors
Rudolph, Michael C.; Jackman, Matthew R.; Presby, David M.; Houck, Julie A.; Webb, Patricia G.; Johnson, Ginger C.; Soderborg, Taylor K.; de la Houssaye, Becky A.; Yang, Ivana V.; Friedman, Jacob E.; MacLean, Paul S.
- Abstract
Adipose tissue expansion progresses rapidly during postnatal life, influenced by both prenatal maternal factors and postnatal developmental cues. The ratio of omega-6 (n-6) relative to n-3 polyunsaturated fatty acids (PUFAs) is believed to regulate perinatal adipogenesis, but the cellular mechanisms and long-term effects are not well understood. We lowered the fetal and postnatal n-6/n-3 PUFA ratio exposure in wild-type offspring under standard maternal dietary fat amounts to test the effects of low n-6/n-3 ratios on offspring adipogenesis and adipogenic potential. Relative to wild-type pups receiving high perinatal n-6/n-3 ratios, subcutaneous adipose tissue in 14-day-old wild-type pups receiving low n-6/n-3 ratios had more adipocytes that were smaller in size; decreased Pparγ2, Fabp4, and Plin1; several lipid metabolism mRNAs; coincident hypermethylation of the PPARγ2 proximal promoter; and elevated circulating adiponectin. As adults, offspring that received low perinatal n-6/n-3 ratios were diet-induced obesity (DIO) resistant and had a lower positive energy balance and energy intake, greater lipid fuel preference and non-resting energy expenditure, one-half the body fat, and better glucose clearance. Together, the findings support a model in which low early-life n-6/n-3 ratios remodel adipose morphology to increase circulating adiponectin, resulting in a persistent adult phenotype with improved metabolic flexibility that prevents DIO.
- Subjects
PROTEIN metabolism; RNA metabolism; ANIMAL experimentation; ANIMAL populations; BLOOD sugar; CARRIER proteins; CELL physiology; COMPARATIVE studies; DIET; ENERGY metabolism; FAT cells; FAT content of food; GENES; GENETIC disorders; INGESTION; LIPID metabolism disorders; RESEARCH methodology; MEDICAL cooperation; MICE; OBESITY; OMEGA-3 fatty acids; OMEGA-6 fatty acids; RESEARCH; RESEARCH funding; EVALUATION research; ADIPONECTIN; DNA methylation; CELL size; PRENATAL exposure delayed effects
- Publication
Diabetes, 2018, Vol 67, Issue 4, p651
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/db17-0890