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- Title
Polystyrene Microplastics Exacerbate Candida albicans Infection Ability In Vitro and In Vivo.
- Authors
Maione, Angela; Norcia, Mariangela; Sinoca, Marica; Galdiero, Marilena; Maselli, Valeria; Feola, Antonia; Carotenuto, Rosa; Cuomo, Paola; Capparelli, Rosanna; Guida, Marco; Galdiero, Emilia
- Abstract
Plastic pollution is an important environmental problem, and microplastics have been shown to have harmful effects on human and animal health, affecting immune and metabolic physiological functions. Further, microplastics can interfere with commensal microorganisms and exert deleterious effects on exposure to pathogens. Here, we compared the effects of 1 µm diameter polystyrene microplastic (PSMPs) on Candida albicans infection in both in vitro and in vivo models by using HT29 cells and Galleria mellonella larvae, respectively. The results demonstrated that PSMPs could promote Candida infection in HT29 cells and larvae of G. mellonella, which show immune responses similar to vertebrates. In this study, we provide new experimental evidence for the risk to human health posed by PSMPs in conjunction with Candida infections.
- Subjects
CANDIDIASIS; MICROPLASTICS; POLYSTYRENE; GREATER wax moth; CANDIDA albicans; ANIMAL health; INSECT nematodes
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 1, p12
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25010012