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- Title
Reduced IQGAP2 Promotes Bladder Cancer through Regulation of MAPK/ERK Pathway and Cytokines.
- Authors
Song, Fei; Kotolloshi, Roland; Gajda, Mieczyslaw; Hölzer, Martin; Grimm, Marc-Oliver; Steinbach, Daniel
- Abstract
The progression of non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive bladder cancer (MIBC) is a major challenge in urologic oncology. However, understanding of the molecular processes remains limited. The dysregulation of IQGAP2 is becoming increasingly evident in most tumor entities, and it plays a role in multiple oncogenic pathways, so we evaluated the role of IQGAP2 in bladder cancer. IQGAP2 was downregulated in tumors compared with normal urothelium tissues and cells. IQGAP2 effectively attenuated bladder cancer cell growth independently from apoptosis. Reduced IQGAP2 promoted EMT in bladder cancer cells via activation of the MAPK/ERK pathway. In addition, IQGAP2 might influence key cellular processes, such as proliferation and metastasis, through the regulation of cytokines. In conclusion, we suggest that IQGAP2 plays a tumor-suppressing role in bladder cancer, possibly via inhibiting the MAPK/ERK pathway and reducing cytokines.
- Subjects
BLADDER cancer; MITOGEN-activated protein kinases; CANCER cell growth; CANCER invasiveness; UROTHELIUM; CYTOKINES
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 21, p13508
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms232113508