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- Title
Anti-Inflammatory Action of Dexmedetomidine on Human Microglial Cells.
- Authors
Yamazaki, Sho; Yamaguchi, Keisuke; Someya, Akimasa; Nagaoka, Isao; Hayashida, Masakazu
- Abstract
Neuroinflammation, where inflammatory cytokines are produced in excess, contributes to the pathogenesis of delirium. Microglial cells play a central role in neuroinflammation by producing and releasing inflammatory cytokines in response to infection, tissue damage and neurodegeneration. Dexmedetomidine (DEX) is a sedative, which reduces the incidence of delirium. Thus, we hypothesized that DEX may alleviate delirium by exhibiting anti-inflammatory action on microglia. In the present study, we investigated the anti-inflammatory action of DEX on human microglial HMC3 cells. The results indicated that DEX partially suppressed the IL-6 and IL-8 production by lipopolysaccharide (LPS)-stimulated HMC3 cells as well as the phosphorylation of p38 MAPK and IκB and the translocation of NF-κB. Furthermore, DEX substantially suppressed IL-6 and IL-8 production by unstimulated HMC3 cells as wells as the phosphorylation of p38 MAPK and IκB and the translocation of NF-κB. These observations suggest that DEX exhibits anti-inflammatory action on not only LPS-stimulated but also unstimulated microglial cells via the suppression of inflammatory signaling and cytokine production.
- Subjects
MICROGLIA; INFLAMMATION; DELIRIUM; MITOGEN-activated protein kinases; DEXMEDETOMIDINE; INTERLEUKIN-6
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 17, p10096
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms231710096